Title Effectiveness of online interventions in preventing depression: a protocol for systematic review and meta-analysis of randomised controlled trials
Authors RIGABERT SÁNCHEZ-JUNCO, ALINA, MOTRICO MARTINEZ , EMMA, Moreno-Peral, Patricia, RESURRECCIÓN MENA, DAVINIA MARÍA, Conejo-Ceron, Sonia, NAVAS CAMPAÑA, DESIRE MARÍA, Bellon, Juan A., MOTRICO MARTINEZ , EMMA, RIGABERT SÁNCHEZ-JUNCO, ALINA, RESURRECCIÓN MENA, DAVINIA MARÍA, NAVAS CAMPAÑA, DESIRE MARÍA
External publication No
Means BMJ Open
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 2.37600
Area International
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057530960&doi=10.1136%2fbmjopen-2018-022012&partnerID=40&md5=250c61556f3ffec84f87bc7712d5437a
Publication date 01/11/2018
ISI 000454740400042
Scopus Id 2-s2.0-85057530960
DOI 10.1136/bmjopen-2018-022012
Abstract Introduction Although evidence exists for the efficacy of psychosocial interventions in preventing depression, little is known about its prevention through online interventions. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials assessing the effectiveness of online interventions in preventing depression in heterogeneous populations. Methods and analysis We will conduct a systematic review and meta-analysis of randomised controlled trials that will be identified through searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Australia New Zealand Clinical Trials Register. We will also search the reference lists provided in relevant studies and reviews. Experts in the field will be contacted to obtain more references. Two independent reviewers will assess the eligibility criteria of all articles, extract data and determine their risk of bias (Cochrane Collaboration Tool). Baseline depression will be required to have been discarded through standardised interviews or validated self-reports with standard cut-off points. The outcomes will be the incidence of new cases of depression and/or the reduction of depressive symptoms as measured by validated instruments. Pooled standardised mean differences will be calculated using random-effect models. Heterogeneity and publication bias will be estimated. Predefined sensitivity and subgroup analyses will be performed. If heterogeneity is relevant, random-effect meta-regression will be performed. Ethics and dissemination The results will be disseminated through peer-reviewed publication and will be presented at a professional conference. Ethical assessment is not required as we will search and assess existing sources of literature. Trial registration number CRD42014014804; Results.
Keywords prevention; online; randomized controlled trial; systematic review; meta-analysis
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