Mejias-Trueba, Marta , Saborido-Alconchel, Abraham , SERNA GALLEGO, ANA DEL ROSARIO, Trujillo-Rodriguez, Maria , Munoz-Muela, Esperanza , Llaves-Flores, Silvia , Espinosa, Nuria , Roca-Oporto, Cristina , Herrero, Marta , Sotomayor, Cesar , Lopez-Cortes, Luis F.
No
Front. Immunol.
Review
Científica
1
1
5.9
29/08/2024
001310232500001
Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4+ T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-beta (MIP-1 beta), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4+/CD8+ ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1 beta, and PTX-3 were unsuitable as predictive markers of poor immune recovery.
HIV infection; IL-6; IP-10; MIP-1 beta; PTX-3; immunologic response