Marmol-Perez, Andres , Ubago-Guisado, Esther , GIL COSANO, JOSÉ JUAN, Rodriguez-Solana, Andrea , B Ortega, Francisco , Mateos Gonzalez, Maria Elena , Pascual-Gazquez, Juan Francisco , J Llorente-Cantarero, Francisco , Cadenas-Sanchez, Cristina , Martinez-Vizcaino, Vicente , K Ness, Kirsten , R Ruiz, Jonatan , Gracia-Marco, Luis
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Arch Phys Med Rehabil
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Científica
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OBJECTIVES: To investigate the effects of a 9-month online bone-strengthening exercise intervention on the femoral neck areal bone mineral density (aBMD) Z-score and other bone health parameters. DESIGN: Assessor-blinded randomized controlled trial with 2 parallel arms. SETTING: Sport and Health University Research Institute (iMUDS). PARTICIPANTS: A total of 116 pediatric cancer survivors aged 6-18 years (12.1 ± 3.3 years; 42% girls). INTERVENTIONS: Before intervention, all participants received dietary counseling on calcium and vitamin D intake. The exercise group performed a 9-month periodized video-recorded bone-strengthening exercise intervention based on squats and jumps (3-4 days/week for 10-20 min/session) at home. MAIN OUTCOME MEASURES: Primary (femoral neck aBMD [g/cm(2)]) and secondary outcomes (aBMD and bone mineral content [BMC, g]) were measured using dual-energy X-ray absorptiometry at the hip regions (femoral neck and total hip), total body, and lumbar spine (mean of L1-L4) at baseline and 9-month post-intervention. RESULTS: No between-group differences in femoral neck aBMD Z-score (Cohen's d?=?-0.08, P?=?.706) and aBMD Z-score outcomes were observed post-intervention. However, the intervention showed small effect sizes on the total hip, with a borderline non-significant improvement in aBMD Z-score (Cohen's d?=?0.35, P?=?.054) and a significant improvement in BMC Z-score (Cohen's d?=?0.38, P?=?.039). CONCLUSIONS: The 9-month online bone-strengthening exercise intervention did not increase the femoral neck aBMD Z-score; however, it improved the overall BMC Z-score at the hip in young pediatric cancer survivors.
Childhood cancer; Oncology; Physical activity; Resistance training; Skeleton