ÁVILA OLÍAS, MARÍA MILAGROS, Pegoraro, Carla , Battaglia, Giuseppe , Canton, Irene
Si
Ther. Deliv.
Review
Científica
0
1
0.608
01/01/2013
000218031500011
2-s2.0-84871580899
Synergy between nanotechnology and drug delivery has created a multitude of novel drug-delivery systems with great therapeutic potential. However, directing these systems across the biological barriers to the target site has proven difficult. Nanotechnology is looking for inspiration in natural systems that have evolved to overcome such barriers. Here, we review nature-inspired strategies and fundamental features common to successful drug-delivery systems across biological barriers.
adenovirus vector; alpha interferon; angiogenesis inhibitor; arginylglycylaspartic acid; cell penetrating peptide; chitosan; DNA fragment; gadoteric acid; immunoliposome; immunological adjuvant; lipid; liposome; macrogol; nanocarrier; nanomaterial; nanoparticle; nucleic acid; oligonucleotide; opsonin; peginterferon alpha; peptide; poly(methyl methacrylate); poly(propylacrilic acid); polyethyleneimine; polymer; polymersome; povidone; small interfering RNA; unclassified drug; unindexed drug; vaccine; biological barrier; biology; biomedicine; blood brain barrier; cell membrane; cell nucleus membrane; cell shape; cell size; cell surface; drug absorption; drug clearance; drug delivery system; drug half life; endocytosis; endosome; erythrocyte membrane; human; hydrophilicity; hydrophobicity; immune response; immunomodulation; micelle; micellization; nanopharmaceutics; nanotechnology; neoplasm; nonhuman; opsonization; priority journal; review; viral gene delivery system