Robertson, James D. , Rizzello, Loris , ÁVILA OLÍAS, MARÍA MILAGROS, Gaitzsch, Jens , Contini, Claudia , Magon, Monika S. , Renshaw, Stephen A. , Battaglia, Giuseppe

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84974623292&doi=10.1038%2fsrep27494&partnerID=40&md5=102ef3aad0019b467592d7c8b0025ec2

08/06/2016

000377463600001

2-s2.0-84974623292

10.1038/srep27494

Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

• MARÍA MILAGROS ÁVILA OLÍAS