Navas Alcantara, Maria Sierra , Montero Rivas, Lorena , Guisado Espartero, Maria Esther , Rubio-Rivas, Manuel , Ayuso Garcia, Blanca , Moreno Martinez, Francisco , Ausin Garcia, Cristina , Taboada Martinez, Maria Luisa , Arnalich Fernandez, Francisco , Martinez Murgui, Raul , Molinos Castro, Sonia , Ramos Munoz, Maria Esther , Fernandez-Garces, Mar , Carreno Hernandez, Mari Cruz , Garcia Garcia, Gema Maria , Vazquez Piqueras, Nuria , Abadia-Otero, Jesica , Lajara Villar, Lourdes , Salazar Monteiro, Cristina , Pascual Perez, Maria de los Reyes , Perez-Martin, Santiago , Collado-Aliaga, Javier , Anton-Santos, Juan-Miguel , Lumbreras-Bermejo, Carlos , SEMI-COVID-19
No
Med. Clin.
Article
Científica
2
3
3.9
0.347
09/09/2022
000862801600002
Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.(c) 2021 Elsevier Espana, S.L.U. All rights reserved.
COVID-19; SARS-CoV-2; Smoking; Mortality; Hospitalized