Quaglio, Deborah , Zhdanovskaya, Nadezda , Tobajas, Gloria , Cuartas, Viviana , Balducci, Silvia , Christodoulou, Michael S. , Fabrizi, Giancarlo , Gargantilla, Marta , Priego, Eva-Maria , CARMONA PESTAÑA, ÁLVARO, Passarella, Daniele , Screpanti, Isabella , Botta, Bruno , Palermo, Rocco , Mori, Mattia , Ghirga, Francesca , Jesus Perez-Perez, Maria

Si

ACS Med. Chem. Lett.

Article

Científica

✗

✓

3.975

1.158

01/04/2019

000464767700043

10.1021/acsmedchemlett.8b00608

Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notchl expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.

Chalcone; tetrahydronaphthalene scaffold; Notch inhibitors; T-ALL; cancer

• ÁLVARO CARMONA PESTAÑA