INFANTE DOMINGUEZ, CARMEN, Salto-Alejandre, Sonsoles , Alvarez-Marin, Rocio , Sabe, Nuria , Ramos-Martinez, Antonio , Moreno, Asuncion , Ferreira de Moraes, Kamilla , Palacios-Baena, Zaira R. , Munoz, Patricia , Fernandez-Ruiz, Mario , Blanes, Marino , Farinas, Carmen , Vidal, Elisa , Merino de Lucas, Esperanza , Halpern, Marcia , Hernandez-Gallego, Roman , Bassetti, Matteo , Mularoni, Alessandra , Gutierrez-Dalmau, Alex , Rinaldi, Matteo , Jimenez-Jorge, Silvia , Bodro, Marta , Aranha-Camargo, Luis Fernando , Valerio, Maricela , Sanchez-Cespedes, Javier , Gutierrez-Gutierrez, Belen , Giannella, Maddalena , Rodriguez-Bano, Jesus , Pachon, Jeronimo , Cordero, Elisa , Covidsot Orchestra Working Teams
No
Sci Rep
Article
Científica
1
1
3.9
03/12/2024
1,45832E+12
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n=394) and vaccinated (n=94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO(2)<95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P=0.04). Patients in the entire cohort were classified into phenotypes A (n=149, 30.5%), B (n=187, 38.3%), and C (n=152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P<0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.
Solid organ transplant recipients; COVID-19; Clinical phenotypes; Mortality; Multicenter cohort study