GIL COSANO, JOSÉ JUAN, Plaza-Florido, Abel , Gracia-Marco, Luis , Migueles, Jairo H. , Cadenas-Sanchez, Cristina , Olvera-Rojas, Marcos , Ubago-Guisado, Esther , Labayen, Idoia , Lucia, Alejandro , Ortega, Francisco B.
No
Pediatr. Obes.
Article
Científica
31/07/2024
001282561500001
2-s2.0-85200140221
BackgroundWe assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.MethodsTotally 109 participants (10.1 +/- 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1 beta, IL-6, leptin, tumour necrosis factor-alpha and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.ResultsNo intervention effect was found for any of the analysed biomarkers (all p >= 0.05). We observed a significant sex by intervention interaction for IL-1 beta (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1 beta levels (mean Z-score difference, 0.66 [95% confidence interval 0.32-1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1 beta (i.e., >= 0.2 standard deviations) than in the control group (15% vs. 85%, p = 0.01).ConclusionsThis exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.
adipokines; cytokines; growth factors; physical exercise; youth