Garcia, Jorge Cea , Maraver, FranciscoMarquez , Jimenez, Inmaculada Rodriguez , Rios-Pena, Laura , Rodriguez, M. Carmen Rubio
No
Indian J. Gynecol. Oncol.
Article
Científica
0.158
01/09/2023
001050066100001
PurposeTo identify prognostic factors and to achieve the internal validation of a predictive model for overall survival in patients with cervical cancer at any stage.MethodsA prospective cohort study was conducted between January 2010 and January 2019 on 229 women with cervical cancer. We performed a survival analysis using the Kaplan-Meier method and log-rank test, and, finally, developed a Cox model.ResultsOverall survival was 41 (IQR = 57.5) months (R = 1-264), with a cancer-specific mortality rate of 26.2%. We found significant differences in the median overall survival between the early and the locally advanced stages (43 versus 11 months, P = 0.001) and between the early and the advanced stages (40 versus 11 months, P = 0.003). There were no significant differences in the 5-year overall survival between the monotherapy based on types B and C2 radical hysterectomy (P = 0.1) and between the radical and the extrafascial hysterectomy (P = 0.2). Regarding the surgical approach for type B radical and total extrafascial hysterectomy, we could not study differences between laparotomic and laparoscopic routes due to a lack of enough amount of power. We developed a model with a Harrell & PRIME;s concordance index of 0.87. The predictors of the model were primary surgery, maximum tumor diameter, and type of therapeutic response.ConclusionThe cancer-specific mortality rate was 26.2%. We developed a model that, once statistical power was increased and externally validated, might provide useful prognostic information for both patients and oncologists at first consultation.
Cancer of the cervix; Endoscopy (laparoscopy and hysteroscopy); Epidemiology of GYN cancers; Research desing; epidemiology and statistics; Surgery in GYN cancers