Body, Setphanie , Cheung, Tim , Valencia-torres, Lourdes , OLARTE SÁNCHEZ, CRISTIAN MANUEL, Fone, Kevin , Bradshaw, Christopher , Szabadi, Elemer
Si
Behav Processes
Article
Científica
1.457
0.797
01/01/2013
000319238700009
In the free-operant psychophysical procedure (FOPP), reinforcement is provided intermittently for responding on lever A in the first half and lever B in the second half of a trial. Temporal differentiation is measured from the psychometric function (percent responding on B, %B, versus time from trial onset, t), the index of timing being T-50, the value of t at %B = 50. T-50 is reduced by acute treatment with 5-hydroxytryptamine (5-HT1A, 5-HT2A) and dopamine (D-1-like, D-2-like) receptor agonists. The effects of the agonists can be reversed by the respective antagonists of these receptors. Evidence is reviewed suggesting that the effect of endogenous 5-HT is mediated by 5-HT2A receptors and the effect of endogenous dopamine by D-1-like receptors. Data are presented on the effects of lesions of the prefrontal cortex and corpus striatum on the sensitivity of performance on the FOPP to D-1-like and D-2-like receptor agonists. Lesions of the nucleus accumbens, but not the dorsal striatum or prefrontal cortex, attenuated the effects of a D-1-like receptor agonist, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine [SKF-81297], but not a D-2-like receptor agonist, quinpirole, on T-50. The results indicate that a population of D-1-like receptors in the ventral striatum may contribute to the control of timing performance on the FOPP. This article is part of a Special Issue entitled: SQAB 2012. (C) 2013 Elsevier B.V. All rights reserved.
Interval timing; Free-operant psychophysical procedure; 5-HT receptors; Dopamine receptors; Prefrontal cortex; Corpus striatum