CUADRADO MÉNDEZ, FRANCISCO JOSÉ, PEREZ, MA , SOTO, JL
No
J. Chem. Soc.-Perkin Trans. 1
Article
Científica
01/01/1984
A1984TP30200039
Methyl N-methoxycarbonylimidates cyclized readily with 2-cyanoacetamide or 2-cyanoethanethioamide to 2,4-dioxopyrimidine-5-carbonitriles or 2-oxo-4-thioxopyrimidine-5-carbonitriles (11) and (12). In analogous reactions with alkyl N-acylimidates, 4-oxopyrimidine-5-carbonitriles or 4-thioxopyrimidine-5-carbonitrile (24) were obtained. Representatives of 4-thioxopyrimidine-5-carbonitriles (11), (24) were methylated to 4-methylthiopyrimidine-5-carbonitriles or cyclized with methyl chloroacetate to give methylthieno[2,3-d]pyrimidine-6-carboxylates.