Codina, Helena , Vieitez, Irene , Gutierrez-Valencia, Alicia , Skouridou, Vasso , Martinez, Cristina , Patino, Lucia , Botero-Gallego, Mariluz , Trujillo-Rodriguez, Maria , SERNA GALLEGO, ANA DEL ROSARIO, Munoz-Muela, Esperanza , Bobillo, Maria M. , Perez, Alexandre , Cabrera-Alvar, Jorge Julio , Crespo, Manuel , O'Sullivan, Ciara K. , Ruiz-Mateos, Ezequiel , Poveda, Eva
No
Microorganisms
Article
Científica
2
2
4.926
0.862
01/11/2021
000723809300001
Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels' decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1 beta at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1 beta, IL-1 beta, MIP-1 alpha and IFN-gamma were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1 beta are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity.
SARS-CoV-2; severe COVID-19; anti-SARS-CoV-2 antibodies; cytokines; viral load