Angeles Rosillo, Maria , Sanchez-Hidalgo, Marina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Gonzalez-Benjumea, Alejandro , Fernandez-Bolanos, Jose G. , Alarcon-de-la-Lastra, Catalina
No
J. Funct. Food.
Article
Científica
1
1
3.47
1.245
01/09/2017
000408518300005
The hallmark of rheumatoid arthritis (RA) pathology is characterized by both hyperproliferation of synovial fibroblasts (SFs) and massive infiltration of inflammatory immune cells. This study was conducted to evaluate the efficacy of hydroxytyrosol (HTy) and hydroxytyrosol-acetate (HTy-Ac) in regulating IL-1 beta-induced production of metalloproteases (MMPs) and proinflammatory cytokines in human synovial cell line. Treatment with HTy or HTy-Ac significantly inhibited IL-1 beta-induced MMPs, tumour necrosis factor (TNF)-alpha and IL-6 production. IL-1 beta-up regulation COX-2 and mPGE-1 was downregulated by HTy and HTy-Ac. IL-1 beta-induced MAPKs phosphorylation and NF-kappa B activation were inhibited by HTy and HTy-Ac. These results suggest that these EVOO phenols reduce the production of proinflammatory mediators in SW982 cells; these protective effects could be related to the inhibition of MAPKs and NF-kappa B signalling pathways. Thus, HTy and HTy-Ac might be promising targets for the prevention and management of diseases associated with overactivation of synovial fibroblasts, like RA. (C) 2017 Elsevier Ltd. All rights reserved.
EVOO; Inflammatory response; Olive oil; Rheumatoid arthritis; Synovial fibroblasts