Rosillo, Maria Angeles , Alarcon-de-la-Lastra, Catalina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Cejudo-Guillen, Marta , Sanchez-Hidalgo, Marina
No
Br. J. Nutr.
Article
Científica
2
1
3.334
1.236
14/01/2019
000454496600006
The polyphenolic extract (PE) from extra virgin olive oil (EVOO) has been shown to possess important anti-inflammatory and joint protective properties in murine models of rheumatoid arthritis (RA). This study was designed to evaluate the effects of PE on IL-1 beta-activated human synovial fibroblasts SW982 cell line. PE from EVOO treatment inhibited IL-1 beta-induced matrix metalloproteases (P<0.001), TNF alpha- and IL-6 production (P<0.001). Similarly, IL-1 beta-induced cyclo-oxygenase-2 and microsomal PGE synthase-1 up-regulations were down-regulated by PE (P<0.001). Moreover, IL-1 beta-induced mitogen-activated protein kinase (MAPK) phosphorylation and NF-kappa B activation were ameliorated by PE (P<0.001). These results suggest that PE from EVOO reduces the production of proinflammatory mediators in human synovial fibroblasts; particularly, these protective effects could be related to the inhibition of MAPK and NF-kappa B signalling pathways. Taken together, PE from EVOO probably could provide an attractive complement in management of diseases associated with over-activation of synovial fibroblasts, such as RA.
Extra virgin olive oil; Olive oil; Polyphenols; Rheumatoid arthritis; Synovial fibroblasts