Título Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids
Autores Avila-Roman, Javier , Garcia-Gil, Sara , RODRÍGUEZ LUNA, AZAHARA MARÍA, Motilva, Virginia , Talero, Elena
Publicación externa Si
Medio MARINE DRUGS
Alcance Review
Naturaleza Científica
Cuartil JCR 1
Cuartil SJR 1
Impacto JCR 6.085
Impacto SJR 0.794
Fecha de publicacion 01/10/2021
ISI 000711369600001
DOI 10.3390/md19100531
Abstract Acute inflammation is a key component of the immune system\'s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as alpha- and beta-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, alpha- and beta-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

Palabras clave microalgae; carotenoids; inflammation; cancer; oxidative stress
Miembros de la Universidad Loyola

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