| Título |
Association of blood-based biomarkers with radiologic markers and cognitive decline in atrial fibrillation patients |
| Autores |
Palà E. , Escudero-Martínez I. , Penalba A. , Bustamante A. , Lamana-Vallverdú M. , Mancha F. , Ocete R.F. , Piñero P. , GALVAO CARMONA, ALEJANDRO, Gómez-Herranz M. , Pérez-Sánchez S. , Moniche F. , González A. , Montaner J. |
| Publicación externa |
No |
| Medio |
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES |
| Alcance |
Article |
| Naturaleza |
Científica |
| Cuartil JCR |
3 |
| Cuartil SJR |
1 |
| Impacto JCR |
2.5 |
| Impacto SJR |
0.713 |
| Web |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140451464&doi=10.1016%2fj.jstrokecerebrovasdis.2022.106833&partnerID=40&md5=4932ec884f85ae0147afb0545a56c2f6 |
| Fecha de publicacion |
01/12/2022 |
| ISI |
000898835100010 |
| Scopus Id |
2-s2.0-85140451464 |
| DOI |
10.1016/j.jstrokecerebrovasdis.2022.106833 |
| Abstract |
Background: Atrial fibrillation (AF) has been associated with an increased risk of silent brain infarcts (SBI) and cognitive impairment, even in patients with low embolic risk. We aimed to test the association between 11 blood-biomarkers representing different AF-related pathways, and SBI, white matter hyperintensities (WMH), and cognitive decline in patients with AF and low embolic risk. Methods: The present study followed a cross-sectional design. 70 patients with a history of AF and CHADS2 score =1, and 10 controls with neither AF nor SBI were included. All patients underwent a 3T brain MRI. Cortical and large subcortical ischemic lesions were considered presumed embolic origin lesions. White matter hyperintensities (WMH) were measured according to the Fazekas scale. A subset of patients underwent cognitive evaluation with the MoCA test. Circulating proteins were measured under blind conditions in a laboratory at Roche Diagnostics, Germany. Results: 45 patients presented SBI in the MRI, and 25 did not. Ang-2, FGF-23, and BMP-10 were increased in patients with SBI. Ang-2 was elevated only in patients with embolic infarcts, whereas FGF-23 and BMP-10 tended to be elevated in patients with both types of infarcts. Ang-2 (OR = 1.56 [0.94-2.59], p = 0.087), and BMP-10 (OR = 4.83 [0.99–23.60], p = 0.052) were the biomarkers that showed the highest association with SBI when entered in a multivariable logistic regression model corrected by age. No biomarker was found associated with WMH or mild cognitive impairment. Conclusions: BMP-10, and Ang-2 were increased in patients with SBI. Its usefulness to detect SBI in AF patients should be further explored. © 2022 Elsevier Inc. |
| Palabras clave |
amino terminal pro brain natriuretic peptide; angiopoietin 2; biological marker; bone morphogenetic protein 10; dickkopf related protein 3 precursor; endothelial cell specific molecule 1; fibroblast growth factor 23; growth differentiation factor 15; insulin like growth factor binding protein 7; interleukin 6; protien; troponin T; unclassified drug; aged; Article; atrial fibrillation; brain damage; brain infarction; CHADS2 score; cognitive defect; controlled study; cross-sectional study; Fazekas scale; female; human; logistic regression analysis; major clinical study; male; mild cognitive impairment; Montreal cognitive assessment; neuroimaging; neurologic disease assessment; nuclear magnetic resonance imaging; white matter lesion |
| Miembros de la Universidad Loyola |
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