Título Association of blood-based biomarkers with radiologic markers and cognitive decline in atrial fibrillation patients
Autores Palà E. , Escudero-Martínez I. , Penalba A. , Bustamante A. , Lamana-Vallverdú M. , Mancha F. , Ocete R.F. , Piñero P. , GALVAO CARMONA, ALEJANDRO, Gómez-Herranz M. , Pérez-Sánchez S. , Moniche F. , González A. , Montaner J.
Publicación externa No
Medio J. Stroke Cerebrovasc. Dis.
Alcance Article
Naturaleza Científica
Cuartil JCR 3
Cuartil SJR 1
Impacto JCR 2.50000
Impacto SJR 0.71300
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140451464&doi=10.1016%2fj.jstrokecerebrovasdis.2022.106833&partnerID=40&md5=4932ec884f85ae0147afb0545a56c2f6
Fecha de publicacion 01/12/2022
ISI 000898835100010
Scopus Id 2-s2.0-85140451464
DOI 10.1016/j.jstrokecerebrovasdis.2022.106833
Abstract Background: Atrial fibrillation (AF) has been associated with an increased risk of silent brain infarcts (SBI) and cognitive impairment, even in patients with low embolic risk. We aimed to test the association between 11 blood-biomarkers representing different AF-related pathways, and SBI, white matter hyperintensities (WMH), and cognitive decline in patients with AF and low embolic risk. Methods: The present study followed a cross-sectional design. 70 patients with a history of AF and CHADS2 score =1, and 10 controls with neither AF nor SBI were included. All patients underwent a 3T brain MRI. Cortical and large subcortical ischemic lesions were considered presumed embolic origin lesions. White matter hyperintensities (WMH) were measured according to the Fazekas scale. A subset of patients underwent cognitive evaluation with the MoCA test. Circulating proteins were measured under blind conditions in a laboratory at Roche Diagnostics, Germany. Results: 45 patients presented SBI in the MRI, and 25 did not. Ang-2, FGF-23, and BMP-10 were increased in patients with SBI. Ang-2 was elevated only in patients with embolic infarcts, whereas FGF-23 and BMP-10 tended to be elevated in patients with both types of infarcts. Ang-2 (OR = 1.56 [0.94-2.59], p = 0.087), and BMP-10 (OR = 4.83 [0.99–23.60], p = 0.052) were the biomarkers that showed the highest association with SBI when entered in a multivariable logistic regression model corrected by age. No biomarker was found associated with WMH or mild cognitive impairment. Conclusions: BMP-10, and Ang-2 were increased in patients with SBI. Its usefulness to detect SBI in AF patients should be further explored. © 2022 Elsevier Inc.
Palabras clave amino terminal pro brain natriuretic peptide; angiopoietin 2; biological marker; bone morphogenetic protein 10; dickkopf related protein 3 precursor; endothelial cell specific molecule 1; fibroblast g
Miembros de la Universidad Loyola

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