Título Clinical Applications of Polypodium leucotomos (Fernblock®): An Update
Autores RODRÍGUEZ LUNA, AZAHARA MARÍA, Zamarron, Alicia , Juarranz, Angeles , Gonzalez, Salvador
Publicación externa Si
Medio LIFE-BASEL
Alcance Review
Naturaleza Científica
Cuartil JCR 1
Cuartil SJR 1
Impacto JCR 3.2
Impacto SJR 0.713
Fecha de publicacion 01/07/2023
ISI 001039512300001
DOI 10.3390/life13071513
Abstract Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock((R)), a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock((R)) and assesses how newly investigated action mechanisms may influence its clinical use.
Palabras clave Polypodium leucotomos; Fernblock(& REG;); photoprotection; photodermatoses; photoaging; hyperpigmentation
Miembros de la Universidad Loyola

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