Pérez-Gómez, Alberto , Vitallé, Joana , Gasca-Capote, Carmen , Gutierrez-Valencia, Alicia , Trujillo-Rodriguez, María , SERNA GALLEGO, ANA DEL ROSARIO, Muñoz-Muela, Esperanza , Jiménez-Leon, María de Los Reyes , Rafii-El-Idrissi Benhnia, Mohamed , Rivas-Jeremias, Inmaculada , Sotomayor, Cesar , Roca-Oporto, Cristina , Espinosa, Nuria , Infante-Domínguez, Carmen , Crespo-Rivas, Juan Carlos , Fernández-Villar, Alberto , Pérez-González, Alexandre , López-Cortés, Luis Fernando , Poveda, Eva , Ruiz-Mateos, Ezequiel , Virgen del Rocío Hospital COVID-19 Working Team , Cisneros, José Miguel , Salto-Alejandre, Sonsoles , Berastegui-Cabrera, Judith , Camacho-Martínez, Pedro , Carretero-Ledesma, Marta , Márquez, Eduardo , Lomas, José Manuel , Bueno, Claudio , Amaya, Rosario , Lepe, José Antonio , Pachón, Jerónimo , Cordero, Elisa , Sánchez-Céspedes, Javier , Aguilar-Guisado, Manuela , Aguilera, Almudena , Aguilera, Clara , Aldabo-Pallas, Teresa , Alfaro-Lara, Verónica , Amodeo, Cristina , Ampuero, Javier , Avilés, María Dolores , Asensio, Maribel , Barón-Franco, Bosco , Barrera-Pulido, Lydia , Bellido-Alba, Rafael , Bernabeu-Wittel, Máximo , Caballero-Eraso, Candela , Cabrera, Macarena , Calderón, Enrique , Carbajal-Guerrero, Jesús , Cid-Cumplido, Manuela , Corcia-Palomo, Yael , Delgado, Juan , Domínguez-Petit, Antonio , Deniz, Alejandro , Dusseck-Brutus, Reginal , Escoresca-Ortega, Ana , Espinosa, Fátima , Espinoza, Michelle , Ferrándiz-Millón, Carmen , Ferrer, Marta , Ferrer, Teresa , Gallego-Texeira, Ignacio , Gámez-Mancera, Rosa , García, Emilio , García-Delgado, Horacio , García-Gutiérrez, Manuel , Gascón-Castillo, María Luisa , González-Estrada, Aurora , González, Demetrio , Gómez-González, Carmen , González-León, Rocío , Grande-Cabrerizo, Carmen , Gutiérrez, Sonia , Hernández-Quiles, Carlos , Herrera-Melero, Inmaculada Concepción , Herrero-Romero, Marta , Jara, Luis , Jiménez-Juan, Carlos , Jiménez-Jorge, Silvia , Jiménez-Sánchez, Mercedes , Lanseros-Tenllado, Julia , López, Carmina , López, Isabel , López-Barrios, Álvaro , López-Cortés, Luis F , Luque-Márquez, Rafael , Macías-García, Daniel , MARTÍN GUTIÉRREZ, GUILLERMO, Martín-Villén, Luis , Molina, José , Morillo, Aurora , Navarro-Amuedo, María Dolores , Nieto-Martín, Dolores , Ortega, Francisco , Paniagua-García, María , Peña-Rodríguez, Amelia , Pérez, Esther , Poyato, Manuel , Praena-Segovia, Julia , Ríos, Rafaela , Rodríguez, Jesús F , Rodríguez-Hernández, María Jesús , Rodríguez-Suárez, Santiago , Rodríguez-Villodres, Ángel , Romero-Rodríguez, Nieves , Ruiz, Ricardo , de Azua, Zida Ruiz , Salamanca, Celia , Sánchez, Sonia , Sánchez-Montagut, Víctor Manuel , Benjumea, Alejandro Suárez , Toral, Javier
No
Cell Mol Immunol
Article
Científica
22.1
2.96
01/09/2021
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-a). In COVID-19 there is a deficit in DC numbers and IFN-a production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin ß7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.
COVID-19; Dendritic cell; Long-COVID; SARS-CoV-2