| Título | Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns |
|---|---|
| Autores | Kinnavane, Lisa , Amin, Eman , OLARTE SÁNCHEZ, CRISTIAN MANUEL, Aggleton, John |
| Publicación externa | Si |
| Medio | Hippocampus |
| Alcance | Article |
| Naturaleza | Científica |
| Cuartil JCR | 2 |
| Cuartil SJR | 1 |
| Impacto JCR | 3.945 |
| Impacto SJR | 2.606 |
| Fecha de publicacion | 01/01/2016 |
| ISI | 000387590300003 |
| DOI | 10.1002/hipo.22615 |
| Abstract | Perirhinal cortex provides object-based information and novelty/familiarity information for the hippocampus. The necessity of these inputs was tested by comparing hippocampal c-fos expression in rats with or without perirhinal lesions. These rats either discriminated novel from familiar objects (Novel-Familiar) or explored pairs of novel objects (Novel-Novel). Despite impairing Novel-Familiar discriminations, the perirhinal lesions did not affect novelty detection, as measured by overall object exploration levels (Novel-Novel condition). The perirhinal lesions also largely spared a characteristic network of linked c-fos expression associated with novel stimuli (entorhinal cortex -> CA3 -> distal CA1 -> proximal subiculum). The findings show: I) that perirhinal lesions preserve behavioral sensitivity to novelty, whilst still impairing the spontaneous ability to discriminate novel from familiar objects, II) that the distinctive patterns of hippocampal c-fos activity promoted by novel stimuli do not require perirhinal inputs, III) that entorhinal Fos counts (layers II and III) increase for novelty discriminations, IV) that hippocampal c-fos networks reflect proximal-distal connectivity differences, and V) that discriminating novelty creates different pathway interactions from merely detecting novelty, pointing to top-down effects that help guide object selection. VC 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc. |
| Palabras clave | entorhinal cortex; hippocampus; nucleus reuniens; prefrontal cortex; recognition memory |
| Miembros de la Universidad Loyola |