| Título | Dynamic Kinetic Resolution of 2-(Quinolin-8-yl)Benzaldehydes: Atroposelective Iridium-Catalyzed Transfer Hydrogenative Allylation |
|---|---|
| Autores | CARMONA CARMONA, JOSÉ ALBERTO, Rodriguez-Salamanca, Patricia , Fernandez, Rosario , Lassaletta, Jose M. , Hornillos, Valentin |
| Publicación externa | Si |
| Medio | Angew. Chem.-Int. Edit. |
| Alcance | Article |
| Naturaleza | Científica |
| Cuartil JCR | 1 |
| Cuartil SJR | 1 |
| Impacto JCR | 16.1 |
| Impacto SJR | 5.3 |
| Fecha de publicacion | 28/08/2023 |
| ISI | 001029742700001 |
| DOI | 10.1002/anie.202306981 |
| Abstract | An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8-yl)benzaldehydes/1-naphthaldehydes by transfer hydrogenative coupling of allyl acetate is disclosed. The allylation reaction takes place with simultaneous installation of central and axial chirality, reaching high diastereoselectivities and excellent enantiomeric excesses when ortho-cyclometalated iridium-DM-BINAP is used as the catalyst. The racemization of the substrates occurs through a designed transient Lewis acid-base interaction between the quinoline nitrogen atom and the aldehyde carbonyl group. |
| Palabras clave | Allylation; Asymmetric Catalysis; Axial Chirality; Iridium Catalysis; Quinolines |
| Miembros de la Universidad Loyola |