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Non-adherence, drug-related problems and negative outcomes associated with medication: causes and outcomes in drug therapy follow-up

Autores

Garcia-Jimenez, E. , Amariles, P. , MACHUCA GONZÁLEZ, MANUEL JESÚS, Parras-Martin, M. , Espejo-Guerrero, J. , Faus, M. J.

Publicación externa

No

Medio

Ars Pharm.

Alcance

Article

Naturaleza

Científica

Cuartil JCR

Cuartil SJR

Impacto SJR

0.27

Fecha de publicacion

01/01/2008

ISI

000210468100006

Abstract

Background: non-adherence continues being an issue of discussion in Pharmaceutical Care, due to the fact that some researches consider non-adherence as a drug related problem (DRPs) and others ones as cause of Negative Outcomes Associated with Medication (NOMs). Thus, we believe that is import to add elements to this discussion, from the perspective of the pharmacotherapy follow-up (PTF). Method: a cross sectional analysis of Pharmacist's interventions on NOMs associated to non-adherence recorded in the Dader Program of PTF of the University of Granada, from January 1st of 2000 to July 31st of 2002. Interventions were included. Results: In total 4485 NOMs were recorded in the Dader program, from January 1st of 2000 to July 31st of 2002. Among this group, an association between the health problems and non-adherence was found in 702 (15.6%) NOMs. The mean (SD) number of prescriptions per identified NOM was of 5.5 (3.2). Chronic health problems were associated to lack of adherence, conversely the acute health problems were associated to excess of use of medication. If the 3 central activities in health assistance (structure, process and clinical outcomes), are complemented with the practice of the pharmacotherapy follow-up this allows the identifi cation and differentiation among the NOMs (outcomes) and the DRPs (failure in the process of medication use that causes NOM, e.g., non-adherence). Conclusion: In this study, non-adherence is associated with 15.6% of NOMs. In view of PTF using the Dader Method, non-adherence is an important cause of NOM.

Palabras clave

Pharmacotherapy follow-up; Negative Outcomes Associated with Medication; Drug-related problem; Nonadherence; Pharmacist's intervention; Dader Program; Dader Method

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