| Título | Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake |
|---|---|
| Autores | D'Agostino, Giuseppe , Lyons, David , Cristiano, Claudia , Lettieri, Miriam , OLARTE SÁNCHEZ, CRISTIAN MANUEL, Burke, Luke K. , Greenwald-Yarnell, Megan , Cansell, Celine , Doslikova, Barbora , Georgescu, Teodora , de Morentin, Pablo Blanco Martinez , Myers, Martin G. , Rochford, Justin J. , Heisler, Lora K. |
| Publicación externa | Si |
| Medio | Cell Metab. |
| Alcance | Article |
| Naturaleza | Científica |
| Cuartil JCR | 1 |
| Cuartil SJR | 1 |
| Impacto JCR | 22.415 |
| Fecha de publicacion | 02/10/2018 |
| ISI | 000446077000012 |
| DOI | 10.1016/j.cmet.2018.07.017 |
| Abstract | To meet the challenge to human health posed by obesity, a better understanding of the regulation of feeding is essential. Medications targeting 5-hydroxytryptamine (5-HT; serotonin) 2C receptors (htr2c; 5-HT2CR) improve obesity. Here we probed the functional significance of 5-HT(2C)Rs specifically within the brainstem nucleus of the solitary tract (5-HT2CRNTS) in feeding behavior. Selective activation of 5-HT2CRNTS decreased feeding and was sufficient to mediate acute food intake reductions elicited by the 5-HT2CR agonist obesity medication lorcaserin. Similar to pro-opiomelanocortin neurons expressed within the hypothalamic arcuate nucleus (POMCARC)a subset of POMCNTS neurons co-ex- pressed 5-HT(2C)Rs and were activated by 5-HT2CR agonists. Knockdown of POMCNTS prevented the acute appetite-suppressive effect of lorcaserin, whereas POMCARC knockdown prevented the full anorectic effect. These data identify 5-HT2CRNTS as a sufficient subpopulation of 5-HT(2C)Rs in reducing food intake when activated and reveal that 5-HT2CR agonist obesity medications require POMC within the NTS and ARC to reduce food intake. |
| Miembros de la Universidad Loyola |