Título Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE®) on Skin Cells against Blue Light Emitted from Digital Devices
Autores Lorrio, Silvia , RODRÍGUEZ LUNA, AZAHARA MARÍA, Delgado-Wicke, Pablo , Mascaraque, Marta , Gallego, Maria , Perez-Davo, Azahara , Gonzalez, Salvador , Juarranz, Angeles
Publicación externa No
Medio INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Alcance Article
Naturaleza Científica
Cuartil JCR 1
Cuartil SJR 1
Impacto JCR 5.923
Impacto SJR 1.455
Fecha de publicacion 01/02/2020
ISI 000522551605027
DOI 10.3390/ijms21030988
Abstract Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices. This, together with recent observations reporting that blue light-also known as high-energy visible light-can exert cytotoxic effects associated with oxidative stress and promote hyperpigmentation, has sparked interest in blue light and its potential harmful effects on skin. The photoprotective properties of new extracts of different botanicals with antioxidant activity are therefore being studied. Deschampsia antarctica (Edafence (R), EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. In this regard, we studied the protective capacity of EDA against the deleterious effects of artificial blue light irradiation in human dermal fibroblasts (HDF) and melanocytes. We analyzed the impact of EDA on viability, cell morphology, oxidative stress, melanogenic signaling pathway activation and hyperpigmentation in HDF and melanocytes subjected to artificial blue light irradiation. Our results show that EDA protects against cell damage caused by artificial blue light, decreasing oxidative stress, melanogenic signaling pathway activation and hyperpigmentation caused by blue light irradiation. All these findings suggest that EDA might help prevent skin damage produced by artificial blue light exposure from screen of electronic devices.
Palabras clave artificial blue light; hyperpigmentation; reactive oxygen species; natural extract; dermal fibroblast; melanocyte
Miembros de la Universidad Loyola

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