Título The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes
Autores Geckin, Buesra , Kilic, Gizem , Debisarun, Priya A. , Fohse, Konstantin , RODRÍGUEZ LUNA, AZAHARA MARÍA, Fernandez-Gonzalez, Pablo , Sanchez, Ana Lopez , Dominguez-Andres, Jorge
Publicación externa No
Medio Frontiers in Immunology
Alcance Article
Naturaleza Científica
Cuartil JCR 1
Cuartil SJR 1
Impacto JCR 5.7
Impacto SJR 1.868
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174849112&doi=10.3389%2ffimmu.2023.1165683&partnerID=40&md5=db4e6e434d2a953a807c7572db66d3b2
Fecha de publicacion 09/10/2023
ISI 001087632600001
Scopus Id 2-s2.0-85174849112
DOI 10.3389/fimmu.2023.1165683
Abstract The proper functioning of the immune system depends on an appropriate balance between pro-inflammation and anti-inflammation. When the balance is disrupted and the system is excessively biased towards inflammation, immune responses cannot return within the normal range, which favors the onset of diseases of autoimmune or inflammatory nature. In this scenario, it is fundamental to find new compounds that can help restore this balance and contribute to the normal functioning of the immune system in humans. Here, we show the properties of a fungal compound with a strong safety profile in humans, AM3, as an immunomodulatory molecule to decrease excessive cytokine production in human cells. Our results present that AM3 treatment of human peripheral blood mononuclear cells and monocytes decreased their pro-inflammatory cytokine secretion following the challenge with bacterial lipopolysaccharide. Additionally, AM3 skewed the differentiation profile of human monocytes to macrophages towards a non-inflammatory phenotype without inducing tolerance, meaning these cells kept their capacity to respond to different stimuli. These effects were similar in young and elderly individuals. Thus, the fungal compound, AM3 may help reduce excessive immune activation in inflammatory conditions and keep the immune responses within a normal homeostatic range, regardless of the age of the individual.
Palabras clave immune response; homeostasis; cytokines; inflammation; AM3; disease; monocytes; macrophages
Miembros de la Universidad Loyola

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