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Publicaciones

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Authors

GONZALEZ CUESTA, MANUEL, Goyard, David , Nanba, Eiji , Higaki, Katsumi , Garcia Fernandez, Jose M. , Renaudet, Olivier , Ortiz Mellet, Carmen

External publication

No

Means

Chem. Commun.

Scope

Article

Nature

Científica

JCR Quartile

1

SJR Quartile

1

JCR Impact

5.996

SJR Impact

1.992

Publication date

04/11/2019

ISI

000495648400019

Abstract

Multivalent mannosides with inherent macrophage recognition abilities, built on beta -cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal beta -glucocerebrosidase or alpha -mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.

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