Title 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
Authors Gracia-Marco, Luis , Gonzalez-Salvatierra, Sheila , Garcia-Martin, Antonia , Ubago-Guisado, Esther , Garcia-Fontana, Beatriz , GIL COSANO, JOSÉ JUAN, Munoz-Torres, Manuel
External publication Si
Means J Clin Med
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 4.96400
SJR Impact 1.04000
Publication date 01/02/2021
ISI 000624007000001
DOI 10.3390/jcm10040657
Abstract The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p > 0.05); however, we found cortical bone impairment (-7.3% to -8.4%; effect size (ES) = 0.78) in AGHD patients (p < 0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (-8.5% to -16.2%; ES = 1.22 to 1.24) with acromegaly patients (p < 0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.
Keywords DXA; bone modelling and remodelling; bone QCT; microCT; osteoporosis
Universidad Loyola members

Change your preferences Manage cookies