Title Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients
Authors Vázquez-Marrufo M., GALVAO CARMONA, ALEJANDRO, Caballero-Díaz R., Borges M., Paramo M.D., Benítez-Lugo M.L., Ruiz-Peña J.L., Izquierdo G., GALVAO CARMONA, ALEJANDRO
External publication No
Means PLoS ONE
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 2.74000
Area International
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069673619&doi=10.1371%2fjournal.pone.0219594&partnerID=40&md5=200fed4ebeba268cb407750644a64709
Publication date 01/01/2019
ISI 000484968200023
Scopus Id 2-s2.0-85069673619
DOI 10.1371/journal.pone.0219594
Abstract Functional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing the patient’s quality of life. A primary objective in the cognitive assessment of multiple sclerosis (MS) patients is to find reliable measures utilizing diverse neuroimaging techniques. Moreover, especially relevant in the clinical environment is finding technical approaches that could be applied to individual participants and not only for group analysis. A 64-channel electroencephalographic recording (EEG) was made with thirty participants divided into three groups of equivalent size (N = 10) (healthy control, low-EDSS (1–2.5) and moderate-EDSS (4–6)). Correlation analysis was applied to multiple measures: behavior, neuropsychological tests (Paced Auditory Serial Addition Test, 3 seconds (PASAT-3s) and the Symbol Digit Modality Test (SDMT)), Expanded Disability Status Scale (EDSS), even-related potential (P3) and event-related desynchronization (ERD) parameters and the correlation scores between individual participant’s P3/ERD maps and the healthy grand average P3/ERDmaps. Statistical analysis showed that diverse parameters exhibited significant correlations. A remarkable correlation was the moderate score found between SDMT and EDSS (r = -0.679, p = 0.0009). However, the strongest correlation was between the value of integrated measures (reaction time, P3 and ERD latency) and EDSS (r = 0.699, p = 0.0006). In regard to correlations for grand average maps between groups, the P3 component exhibited a lower score according to a more deteriorated condition (higher EDSS). In contrast, ERD maps remained stable with an increase of EDSS. Lastly, a Z-transformation of individual values of all variables included in the study exhibited heterogeneity in cognitive alterations in the multiple sclerosis participants. © 2019 Vázquez-Marrufo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords adult; Article; clinical article; controlled study; electroencephalography; event related potential; evoked response; Expanded Disability Status Scale; female; human; latent period; male; multiple scl
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