Title Cardiorespiratory Fitness and Bone Turnover Markers in Adults With Metabolic Syndrome: The Mediator Role of Inflammation
Authors GIL COSANO, JOSÉ JUAN, Gracia-Marco L. , Courteix D. , Lesourd B. , Chapier R. , Obert P. , Walther G. , Vinet A. , Thivel D. , Muñoz-Torres M. , Ugbolue U.C. , Bagheri R. , Zak M. , Dutheil F. , Ubago-Guisado E.
External publication No
Means Int J Sport Nutr Exerc Metab
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144597485&doi=10.1123%2fijsnem.2022-0109&partnerID=40&md5=bd4180fc577e3cc4bb9dd703d494cf0a
Publication date 01/01/2023
ISI 000974737200003
Scopus Id 2-s2.0-85144597485
DOI 10.1123/ijsnem.2022-0109
Abstract The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5 ± 5.0 years, 62.7% women) were included in the analysis. CRF was measured by the 6-min walking test. Serum interleukin (IL)-1ß, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP), and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy X-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers, and bone turnover markers, controlling for sex, lean mass, and fat mass. Boot-strapped mediation procedures were performed, and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r = .228, p = .044) and osteocalcin levels (r = .296, p = .009). Furthermore, CRF was positively correlated with IL-1ß levels (r = .340, p = .002) and negatively correlated with hsCRP levels (r = -.335, p = .003), whereas IL-1ß levels were positively correlated with P1NP levels (r = .245, p = .030), and hsCRP levels were negatively correlated with P1NP levels (r = -.319, p = .004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (percentage of mediation = 39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population.
Keywords biological marker; C reactive protein; osteocalcin; Procollagen Type I; vasculotropin A; adult; bone density; bone remodeling; cardiorespiratory fitness; female; human; inflammation; male; metabolic s
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