| Title | Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia |
|---|---|
| Authors | Quaglio, Deborah , Zhdanovskaya, Nadezda , Tobajas, Gloria , Cuartas, Viviana , Balducci, Silvia , Christodoulou, Michael S. , Fabrizi, Giancarlo , Gargantilla, Marta , Priego, Eva-Maria , CARMONA PESTAÑA, ÁLVARO, Passarella, Daniele , Screpanti, Isabella , Botta, Bruno , Palermo, Rocco , Mori, Mattia , Ghirga, Francesca , Jesus Perez-Perez, Maria |
| External publication | Si |
| Means | ACS Med. Chem. Lett. |
| Scope | Article |
| Nature | Científica |
| JCR Quartile | 2 |
| SJR Quartile | 1 |
| JCR Impact | 3.975 |
| SJR Impact | 1.158 |
| Publication date | 01/04/2019 |
| ISI | 000464767700043 |
| DOI | 10.1021/acsmedchemlett.8b00608 |
| Abstract | Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notchl expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent. |
| Keywords | Chalcone; tetrahydronaphthalene scaffold; Notch inhibitors; T-ALL; cancer |
| Universidad Loyola members |