Marmol-Perez A. , Ubago-Guisado E. , Llorente-Cantarero F.J. , Vlachopoulos D. , Rodriguez-Solana A. , GIL COSANO, JOSÉ JUAN, Ruiz J.R. , Gracia-Marco L.
No
Pediatr Res
Article
Científica
3.1
1.184
18/05/2023
000992096500004
2-s2.0-85159662040
Background: Bone health is remarkably affected by endocrine side effects due to paediatric cancer treatments and the disease itself. We aimed to provide novel insights into the contribution of independent predictors of bone health in young paediatric cancer survivors. Methods: This cross-sectional multicentre study was carried out within the iBoneFIT framework in which 116 young paediatric cancer survivors (12.1 ± 3.3 years old; 43% female) were recruited. The independent predictors were sex, years from peak height velocity (PHV), time from treatment completion, radiotherapy exposure, region-specific lean and fat mass, musculoskeletal fitness, moderate-vigorous physical activity and past bone-specific physical activity. Results: Region-specific lean mass was the strongest significant predictor of most areal bone mineral density (aBMD), all hip geometry parameters and Trabecular Bone Score (ß = 0.400–0.775, p = 0.05). Years from PHV was positively associated with total body less head, legs and arms aBMD, and time from treatment completion was also positively associated with total hip and femoral neck aBMD parameters and narrow neck cross-sectional area (ß = 0.327–0.398, p = 0.05; ß = 0.135–0.221, p = 0.05), respectively. Conclusion: Region-specific lean mass was consistently the most important positive determinant of all bone parameters, except for total hip aBMD, all Hip Structural Analysis parameters and Trabecular Bone Score. Impact: The findings of this study indicate that region-specific lean mass is consistently the most important positive determinant of bone health in young paediatric cancer survivors.Randomised clinical trials focused on improving bone parameters of this population should target at region-specific lean mass due to the site-specific adaptations of the skeleton to external loading following paediatric cancer treatment.After paediatric cancer diagnosis, years from peak height velocity (somatic maturity) is critical for bone development. © 2023, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
calcium; vitamin D; anthropometry; arm; Article; body composition; body mass; bone; bone density; bone mineral; bone quality; calcium intake; cancer radiotherapy; child; childhood cancer survivor; controlled study; dual energy X ray absorptiometry; fat mass; female; femoral neck; fitness; food frequency questionnaire; ground reaction force; head; hematopoietic stem cell transplantation; hip; human; leg; lumbar spine; major clinical study; male; multicenter study; musculoskeletal system parameters; physical activity; randomized controlled trial; sun exposure; trabecular bone