Title Gender differences in quality of life in adults with long-standing type 1 diabetes mellitus
Authors Maria Castellano-Guerrero, Ana , Guerrero, Raquel , RUIZ ARANDA, DESIREE, Perea, Sofia , Pumar, Alfonso , Relimpio, Federico , Angel Mangas, Miguel , Losada, Fernando , Asuncion Martinez-Brocca, Maria
External publication No
Means Diabetol. Metab. Syndr.
Scope Article
Nature Científica
JCR Quartile 3
SJR Quartile 2
JCR Impact 3.32000
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088465086&doi=10.1186%2fs13098-020-00571-x&partnerID=40&md5=4f39df9a623ca8558aecd4746b8ad4c9
Publication date 17/07/2020
ISI 000552393800001
Scopus Id 2-s2.0-85088465086
DOI 10.1186/s13098-020-00571-x
Abstract Background To assess gender differences in Quality of life (QoL) and in\n sociodemographic, clinical and psychological factors associated with\n impaired QoL in adults with long-standing type 1 diabetes mellitus\n (DM1). Methods Cross-sectional evaluation in a random cohort of DM1\n adult patients from a tertiary care hospital. QoL was evaluated using\n translated and validated self-administered Diabetes QoL questionnaire\n (Es-DQoL), and results transformed into a 0-100 scale. Psychological\n assessment included a planned psychological interview and self-reported\n questionnaires (Beck Depression Inventory II, State-Trait Anxiety\n Inventory Form Y, Fear of hypoglycaemia Scale, Medical Outcomes Study\n Social Support Survey). Results A total of 312 patients (51.6% male;\n 38.2 +/- 12.7 years; HbA(1c)7.5 +/- 1.1% (58.5 +/- 14.2 mmol/mol); 20.4\n +/- 12.0 years of DM1) were included in the analysis. Male and female\n subgroups showed similar sociodemographic and diabetes-related features\n and comparable social support. Among female patients, higher frequency\n of depression [31.7% (IC95% 26.2-40.8) vs. 14.9% (IC95% 10.1-20.8), p <\n 0.05] and anxiety [23.2% (IC95% 19.3-33.14) vs. 13.0% (IC95% 8.1-18.4),\n p < 0.05] and severity of depressive and anxious symptoms were also\n found. Compared to male patients, female patients showed lower QoL [75\n (IC95% 73.6-77.5) vs. 80 (IC95% 75.7-83.1), p < 0.05] and scored\n significantly worse in subscale Diabetes-related worries [69 (IC95%\n 50.0-81.0) vs. 75 (IC95% 72.9-79.0), p < 0.05]. Fear of hypoglycemia and\n severity of depressive and anxious symptoms were factors independently\n associated to lower QoL in men and women while high frequency of\n glycemic excursions was a female-specific predictive one. Conclusions\n Adult women with long-standing DM1 showed lower QoL probably related to\n higher frequency and severity of psychopathological syndromes.\n Depressive and anxious symptoms and, among women, exposure to glycemic\n excursions were identified as modifiable, QoL-related variables.\n Educational, technological and psychological interventions are needed in\n order to improve QoL in DM1 patients.
Keywords Type 1 diabetes mellitus; Quality of life; Gender differences
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