Title The effect of prioritization over cognitive-motor interference in people with relapsing-remitting multiple sclerosis and healthy controls
Authors POSTIGO ALONSO, BÁRBARA, GALVAO CARMONA, ALEJANDRO, Conde-Gavilán C., Jover A., Molina S., Peña-Toledo M.A., Valverde-Moyano R., Agüera E., GALVAO CARMONA, ALEJANDRO, POSTIGO ALONSO, BÁRBARA
External publication No
Means PLoS ONE
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 2.74000
Area International
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077200413&doi=10.1371%2fjournal.pone.0226775&partnerID=40&md5=c9f30f4dc2a07da26bfa6414029b997f
Publication date 01/01/2019
ISI 000515082600051
Scopus Id 2-s2.0-85077200413
DOI 10.1371/journal.pone.0226775
Abstract The cognitive-motor interference (CMI) produced by simultaneous performance of a cognitive and a motor task has been proposed as a marker of real-life impairment of people with Multiple Sclerosis (pwMS), yet there is no consensus on the dual task (DT) procedure. This study aimed to compare DT performance of pwMS and healthy controls (HC) under different instructions and to examine its association with neuropsychological and clinical variables. PwMS (N = 23; relapsing-remitting course) and HC (N = 24) completed the cognitive (Verbal Fluency) and motor (walking) tasks under three conditions: independently or as single task (ST), both tasks simultaneously at best capacity or double prioritization (DT-DP), and only the cognitive task at best capacity while walking at preferred speed or cognitive prioritization (DT-CP). Compared to HC, pwMS walked significantly slower and produced less correct words under all conditions. The distance walked by pwMS and HC significantly differed between conditions (DT-CP< DT-DP< ST). PwMS produced more words during ST respective to DT-DP and DT-CP, with no difference between both DT conditions. HC showed no differences in cognitive performance between conditions. Motor and cognitive dual-task costs (DTC) were similar between groups. Only in pwMS, the cognitive DTC of DT-DP was different from zero. CMI measures correlated with neuropsychological, symptomatic, physiological (cognitive event-related potentials) and clinical variables. These results suggest that cognitive performance while walking is impaired in pwMS, but not in HC. CMI over cognitive performance might be a potential early marker of cognitive decline in pwMS, which may be enhanced by the instruction to prioritize both tasks in DT. © 2019 Postigo-Alonso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords adult; amplitude modulation; Article; case control study; clinical article; cognition; controlled study; disease association; disease duration; electroencephalogram; episodic memory; event related pot
Universidad Loyola members