Title Tissue engineering using novel rapid prototyped diamond-like carbon coated scaffolds
Authors Lantada A.D. , ENDRINO ARMENTEROS, JOSÉ LUIS, Vaquero V.S. , Mosquera A. , Lafont P. , García-Ruiz J.P.
External publication Si
Means Plasma Process. Polym.
Scope Article
Nature Científica
JCR Quartile 1
SJR Quartile 1
JCR Impact 3.73000
SJR Impact 1.21200
Web https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855560476&doi=10.1002%2fppap.201100094&partnerID=40&md5=0f58460c16362b10311b033704ee0608
Publication date 01/01/2012
ISI 000298842100013
Scopus Id 2-s2.0-84855560476
DOI 10.1002/ppap.201100094
Abstract In this study we investigate an alternative method for designing and obtaining novel scaffolds for analyzing the influence of geometries on tissue engineering processes. The method is based on the combination of conventional and accessible rapid prototyping technologies with plasma processing using a hydrogen-free diamond-like carbon (DLC) coating in order to improve cell-tissue interactions. The proposed method allows a precise control of scaffold structure and enables in vitro studies linked to cell growth and tissue formation because of the highly biocompatible DLC surface. Several designs with different hole sizes and surface topographies have been manufactured for subsequent in vitro study of human mesenchymal stem cell (hMSC) growth and aggregation, so as to validate our approach. A method for designing and manufacturing novel polymeric scaffolds for tissue engineering is presented. The process is based on the combination of conventional and accessible rapid prototyping technologies with surface functionalization using a highly biocompatible diamond-like carbon (DLC) coating to improve cell-tissue interactions. Results from in vivo trials and potential implications are discussed. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords Alternative methods; Diamond-like carbon; Diamond-like carbon coatings; Engineering process; Hole size; Human mesenchymal stem cells; In-vitro; In-vivo; Polymeric scaffold; Precise control; Rapid prot
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