MORENO LUNA, RAMÓN, Abrante, Antonio , Esteban, Francisco , Angel Gonzalez-Moles, Miguel , Delgado-Rodriguez, Miguel , Eugenia Saez, Maria , GONZÁLEZ PÉREZ, ANTONIO, Ramirez-Lorca, Reposo , Miguel Real, Luis , Ruiz, Agustin
No
Head Neck-J. Sci. Spec. Head Neck
Article
Científica
2.403
1.14
01/01/2011
000286290400011
Background. Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+-dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival. Methods. Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model. Results. UCSNP-19, UCSNP-43, and UCSNP-44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP-63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21-6.20). Conclusion. CAPN10 UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 72-76, 2011
laryngeal cancer; polymorphism; CAPN10; UCSNP-63; calpains