Esteban, F. , Royo, J. L. , Gonzalez-Moles, M. A. , Gonzalez-Perez, A. , Redondo, M. , MORENO LUNA, RAMÓN, Rodriguez-Sola, M. , Gonzalez, A. , Real, L. M. , Ruiz, A. , Ramirez-Lorca, R.
No
EJSO
Article
Científica
2.491
1.12
01/01/2008
000252771200017
Aims: Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. To date, CAPN10 has been found to be extensively associated with hyperinsulinaemia and type 2 diabetes mellitus, by different groups. In addition, some reports have shown evidence that hyperinsulinaemia exerts a protective effect on laryngeal cancer risk. On the other hand, low circulating levels of IGF-1 have been recently found in patients with laryngeal carcinoma. Our objective was to examine the contribution of CAPN10 alleles to the development of laryngeal cancer. Methods: Cases and controls were recruited from central and southern Spain. Genotypes were determined using pyrosequencing technology. We analysed CAPN10 UCSNP-44, -43, -19, and -63 allelic distribution in 218 unrelated laryngeal cancer patients and 606 controls from the general population. Results: We found that the UCSNP-44 allele-C is significantly under-represented among patients with laryngeal cancer (OR = 0.685, p = 0.02). Conclusion: These results indicate that some CAPN10 alleles may be exerting a protective effect on laryngeal cancer risk in the Spanish population. (c) 2007 Elsevier Ltd. All rights reserved.
laryngeal cancer; polymorphism; CAPN10; UCSNP-44