| Título |
Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial |
| Autores |
GIL COSANO, JOSÉ JUAN, Plaza-Florido, Abel , Gracia-Marco, Luis , Migueles, Jairo H. , Cadenas-Sanchez, Cristina , Olvera-Rojas, Marcos , Ubago-Guisado, Esther , Labayen, Idoia , Lucia, Alejandro , Ortega, Francisco B. |
| Publicación externa |
No |
| Medio |
Pediatric Obesity |
| Alcance |
Article |
| Naturaleza |
Científica |
| Cuartil JCR |
1 |
| Cuartil SJR |
1 |
| Web |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85200140221&doi=10.1111%2fijpo.13152&partnerID=40&md5=283fd1fb61902d663b889a79512b6767 |
| Fecha de publicacion |
31/07/2024 |
| ISI |
001282561500001 |
| Scopus Id |
2-s2.0-85200140221 |
| DOI |
10.1111/ijpo.13152 |
| Abstract |
BackgroundWe assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.MethodsTotally 109 participants (10.1 +/- 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1 beta, IL-6, leptin, tumour necrosis factor-alpha and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.ResultsNo intervention effect was found for any of the analysed biomarkers (all p >= 0.05). We observed a significant sex by intervention interaction for IL-1 beta (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1 beta levels (mean Z-score difference, 0.66 [95% confidence interval 0.32-1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1 beta (i.e., >= 0.2 standard deviations) than in the control group (15% vs. 85%, p = 0.01).ConclusionsThis exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet. |
| Palabras clave |
adipokines; cytokines; growth factors; physical exercise; youth |
| Miembros de la Universidad Loyola |
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