Title Acoustic characterization of monodisperse lipid-coated microbubbles: Relationship between size and shell viscoelastic properties
Authors PARRALES BORRERO, MIGUEL ÁNGEL, Fernandez, Juan M. , Perez-Saborid, Miguel , Kopechek, Jonathan A. , Porter, Tyrone M.
External publication No
Means J. Acoust. Soc. Am.
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 1.503
SJR Impact 0.887
Publication date 01/09/2014
ISI 000342205700021
DOI 10.1121/1.4890643
Abstract The acoustic attenuation spectrum of lipid-coated microbubble suspensions was measured in order to characterize the linear acoustic behavior of ultrasound contrast agents. For that purpose, microbubbles samples were generated with a very narrow size distribution by using microfluidics techniques. A performance as good as optical characterization techniques of single microbubbles was achieved using this method. Compared to polydispersions (i.e., contrast agents used clinically), monodisperse contrast agents have a narrower attenuation spectrum, which presents a maximum peak at a frequency value corresponding to the average single bubble resonance frequency. The low polydispersity index of the samples made the estimation of the lipid viscoelastic properties more accurate since, as previously reported, the shell linear parameters may change with the equilibrium bubble radius. The results showed the great advantage of dealing with monodisperse populations rather than polydisperse populations for the acoustic characterization of ultrasound contrast agents. (C) 2014 Acoustical Society of America.
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