Title Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications
Authors Cidade, M. T. , Ramos, D. J. , SANTOS GARCÍA, JENIFER, Carrelo, H. , Calero, N. , Borges, J. P.
External publication Si
Means Materials (Basel)
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 2
JCR Impact 3.05700
SJR Impact 0.64700
Publication date 10/04/2019
ISI 000465500700082
DOI 10.3390/ma12071083
Abstract A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.
Keywords Pluronic; water systems; alginate microparticles; composites; injectable gels; rheology; dual cargo delivery systems
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