La Dra. María Luisa Castejón Martínez es Personal Docente e Investigador en la Universidad Loyola Andalucía, acreditada por ANECA como Profesora Contratado Doctor, además ejerce como docente en asignaturas afines al área de Farmacología en diferentes grados como Farmacia, Enfermería, Biotecnología y Fisioterapia. Además, es coordinadora de quinto curso y del Programa de Prácticas Tuteladas del Grado en Farmacia de la ULA. Su actividad científica se ha centrado en el estudio de compuestos bioactivos y nutracéuticos derivados del aceite de oliva y otros recursos vegetales, analizando sus efectos en procesos inmunoinflamatorios mediante aproximaciones farmacológicas y moleculares. Sus líneas de investigación se orientan al desarrollo y evaluación preclínica de estrategias terapéuticas basadas en compuestos naturales aplicadas a la mejora de la salud humana.Su trayectoria científica es sólida gracias a la financiación competitiva que ha duda lugar a importantes proyectos en los que ha participado como parte del equipo de trabajo. En particular, ha participado en 7 proyectos de investigación (nacionales). Ha realizado contribuciones significativas en los campos de la farmacología y la biología molecular. Todo ello está avalado por 31 publicaciones científicas (Índice H: 16; 95.2% Q1 JCR con un total de 845 citas), 41 comunicaciones en congresos nacionales e internacionales, con la obtención de varios premios por la mejor comunicación presentada. Además, ha participado en el comité organizador de varios congresos. Es revisora de varias revistas científicas, miembro de la Sociedad Española de Farmacología y ha sido miembro de la Comisión Nacional de Jóvenes Investigadores en Farmacología.
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Health-Promoting Properties of Pectin-Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities Bermudez-Oria, Alejandra , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Rubio-Senent, Fatima , Rodriguez-Gutierrez, Guillermo , Fernandez-Bolanos, Juan 01/09/2024 Article |
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Isolation and structural determination of cis- and trans-p-coumaroyl-secologanoside (comselogoside) from olive oil waste (alperujo). Photoisomerization with ultraviolet irradiation and antioxidant activities Bermudez-Oria, Alejandra , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Rubio-Senent, Fatima , Fernandez-Prior, Africa , Rodriguez-Gutierrez, Guillermo , Fernandez-Bolanos, Juan 30/01/2024 Article |
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Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum), in an Ex Vivo Mouse Model of LPS-Induced Inflammation Alcarranza M. , Alarcón-De-la-Lastra C. , Recio Jiménez R. , Fernández I. , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Villegas I. 01/01/2024 Article |
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An Acid-Free Alternative to Pectin Production from the Cell Walls of Olive Oil Waste and Different Fruits Using Choline Chloride Bermudez-Oria, Alejandra , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Fernandez-Prior, Africa , Rodriguez-Gutierrez, Guillermo , Fernandez-Bolanos, Juan 01/11/2023 Article |
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Extraction of polyphenols associated with pectin from olive waste (alperujo) with choline chloride Bermudez-Oria, Alejandra , Fernandez-Prior, Africa , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Rodriguez-Gutierrez, Guillermo , Fernandez-Bolanos, Juan 01/09/2023 Article |
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Epigenetic linkage of systemic lupus erythematosus and nutrition Montoya, Tatiana , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Munoz-Garcia, Rocio , Alarcon-de-la-Lastra, Catalina 01/06/2023 Review |
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Oleocanthal supplemented diet improves renal damage and endothelial dysfunction in pristane-induced systemic lupus erythematosus in mice Montoya, Tatiana , Sanchez-Hidalgo, Marina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Victoria Vazquez-Roman, Maria , Alvarez de Sotomayor, Maria , Ortega-Vidal, Juan , Luisa Gonzalez, Maria , Alarcon-de-la-Lastra, Catalina 01/01/2023 Article |
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Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-?B, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Ortega-Vidal, Juan , Altarejos, Joaquin , Alarcon-de-la-Lastra, Catalina 03/10/2022 Article |
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(-)-Methyl-Oleocanthal, a New Oleocanthal Metabolite Reduces LPS-Induced Inflammatory and Oxidative Response: Molecular Signaling Pathways and Histones Epigenetic Modulation Montoya, Tatiana , Alarcon-de-la-Lastra, Catalina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Ortega-Vidal, Juan , Altarejos, Joaquin , Sanchez-Hidalgo, Marina 01/01/2022 Article |
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Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice Montoya, Tatiana , Sanchez-Hidalgo, Marina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Rosillo, Maria Angeles , Gonzalez-Benjumea, Alejandro , Alarcon-de-la-Lastra, Catalina 01/05/2021 Article |
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A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-?B Activation CASTEJÓN MARTÍNEZ, MARÍA LUISA, Alarcon-de-la-Lastra, Catalina , Angeles Rosillo, Maria , Montoya, Tatiana , Fernandez-Bolanos, Jose G. , Gonzalez-Benjumea, Alejandro , Sanchez-Hidalgo, Marina 01/02/2021 Article |
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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, T. , Alarcon-de-la-Lastra, C. , Gonzalez-Benjumea, A. , Vazquez-Roman, M. V. , Sanchez-Hidalgo, M. 01/07/2020 Article |
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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function Angeles Rosillo, Maria , Montserrat-de-la-Paz, Sergio , Abia, Rocio , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Carmen Millan-Linares, Maria , Alarcon-de-la-Lastra, Catalina , Fernandez-Bolanos, Jose G. , Muriana, Francisco J. G. 01/05/2020 Article |
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Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Alarcon-de-la-Lastra, Catalina , Sanchez-Hidalgo, Marina 01/02/2020 Review |
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Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-?B, MAPK and NLRP3 inflammasome signaling pathways CASTEJÓN MARTÍNEZ, MARÍA LUISA, Sanchez-Hidalgo, M. , Aparicio-Soto, M. , Montoya, T. , Martin-LaCave, I. , Fernandez-Bolanos, J. G. , Alarcon-de-la-Lastra, C. 01/12/2019 Article |
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Dietary oleuropein and its new acyl-derivative attenuate murine lupus nephritis through HO1/Nrf2 activaction and suppressing JAK/STAT, NF-kB, MAPK and NLRP3 inflammasome signalling pathways CASTEJÓN MARTÍNEZ, MARÍA LUISA, Sánchez Hidalgo, Marina , Aparicio Soto, Marina , Montoya, Tatiana , Martín La-Cave, Inés , Fernández-Bolaños, Jose G. , Alarcón-de-la-Lastra Romero, Catalina 13/09/2019 Article |
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Olive secoiridoid oleuropein and its semisynthetic acetyl-derivatives reduce LPS-induced inflammatory response in murine peritoneal macrophages via JAK-STAT and MAPKs signaling pathways CASTEJÓN MARTÍNEZ, MARÍA LUISA, Sanchez-Hidalgo, Marina , Aparicio-Soto, Marina , Gonzalez-Benjumea, Alejandro , Fernandez-Bolanos, Jose G. , Alarcon-de-la-Lastra, Catalina 01/07/2019 Article |
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Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways Montoya, Tatiana , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Sanchez-Hidalgo, Marina , Gonzalez-Benjumea, Alejandro , Fernandez-Bolanos, Jose G. , Alarcon-de-la-Lastra, Catalina 15/05/2019 Article |
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Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats CASTEJÓN MARTÍNEZ, MARÍA LUISA, Angeles Rosillo, Maria , Villegas, Isabel , Sanchez-Hidalgo, Marina , Hadidi, Lila , Zaidi, Farid , Alarcon-de-la-Lastra, Catalina 01/05/2019 Article |
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Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1ß-activated synovial fibroblasts Rosillo, Maria Angeles , Alarcon-de-la-Lastra, Catalina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Cejudo-Guillen, Marta , Sanchez-Hidalgo, Marina 14/01/2019 Article |
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Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways Lopes de Oliveira, Guilherme Antonio , Alarcon-de-la-Lastra, Catalina , Angeles Rosillo, Maria , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Sanchez-Hidalgo, Marina , Rolim Medeiros, Jand Venes , Villegas, Isabel 05/01/2019 Article |
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Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways Montoya, Tatiana , Aparicio-Soto, Marina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Angeles Rosillo, Maria , Sanchez-Hidalgo, Marina , Begines, Paloma , Fernandez-Bolanos, Jose G. , Alarcon-de-la-Lastra, Catalina 01/07/2018 Article |
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Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells Angeles Rosillo, Maria , Sanchez-Hidalgo, Marina , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Montoya, Tatiana , Gonzalez-Benjumea, Alejandro , Fernandez-Bolanos, Jose G. , Alarcon-de-la-Lastra, Catalina 01/09/2017 Article |
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Oleuropein down-regulated IL-1ß-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982 CASTEJÓN MARTÍNEZ, MARÍA LUISA, Angeles Rosillo, Maria , Montoya, Tatiana , Gonzalez-Benjumea, Alejandro , Maria Fernandez-Bolanos, Jose , Alarcon-de-la-Lastra, Catalina 01/05/2017 Article |
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Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases Aparicio-Soto, Marina , Sanchez-Hidalgo, Marina , Angeles Rosillo, Ma , CASTEJÓN MARTÍNEZ, MARÍA LUISA, Alarcon-de-la-Lastra, Catalina 01/01/2016 Review |